Sildenafil, the more affordable yet equally effective generic version of Viagra, stays active in the body for about four to six hours. This medication reaches its maximum concentrations in approximately an hour, so it is usually best to take it 30 to 60 minutes before planned sexual activity. Once it becomes entirely effective in the body, this medication treats erectile dysfunction (ED) by enhancing blood flow to the penis.
The average half-life of sildenafil citrate is 3 to 5 hours, which is the length of time it takes for the body to eliminate half the medication. However, several factors can influence the durational efficacy of this treatment. The following table contains some of the points that can affect how long this medication lasts:
|Influencing factor||How the factor influences the duration of effect|
|The age of a patient||In general, the metabolism slows down as a person gets older. For this reason, individuals who are over the age of 65 may find that the effects of this medication last longer.|
|Lifestyle factors||The use of alcohol can reduce genital blood flow and affect the way this medication works, resulting in a shorter duration of action.|
|Diet||Taking this medication on a full stomach or with high-fat foods can delay the onset of effects because food affects the absorption rate. Taking this medication with food can, however, prolong the effects as the body takes longer to metabolise the medication.|
|General health||Physical health conditions like multiple sclerosis can decrease the durational efficacy of this medicine. In contrast, patients with kidney problems may find this medication lasts longer because it takes longer for the body to metabolize it.|
In general, the dosage that you use will affect the duration of action. Essentially, the larger the dose, the longer it will last. A placebo-controlled study was conducted to evaluate the duration of action of this medication in men with erection problems. In total, 16 men between the ages of 38 and 68 years with erectile dysfunction were involved in the study. They received sildenafil 100 mg or inactive placebo tablets to take 1, 8 or 12 hours before visual sexual stimulation.
A device called a penile plethysmograph, which measures the flow of blood to the penis, was used to determine results. In addition, the men recorded their own assessments during the study. From the penile plethysmograph, the following results were recorded for erections with a rigidity of at least 60%:
For placebo, which is an inactive treatment, erections lasted only 3 minutes at all three intervals. The results for the self-assessed records showed that the average duration of erections was slightly longer than what was recorded by the penile plethysmograph. The study found that a 100 mg dose of this erectile dysfunction treatment may still be effective in a considerable proportion of men up to 12 hours after taking a dose. Nevertheless, this medication is known to exert its peak effects between 30 minutes and 2.5 hours of administration. It is therefore best to take it 30 to 60 minutes before sexual activity.
A lower dose of 50 mg will typically take less time to wear off than a 100 mg dose. In general, a 50 mg dose will stay effective for half the length of time as a 100 mg dose. Therefore, you can expect a sildenafil 50 mg dose to stay effective in the body for about two to three hours. Another study took place to assess the time to onset of erections among men who received a 50 mg dose of this medicine. A total of 17 men with ED were included in this study. Visual sexual stimulation and a penile plethysmograph were also used to determine outcomes. After receiving a 50 mg dose of this ED treatment, the following results were recorded:
If you find a 50 mg dose of this erectile dysfunction medication is effective with few side effects, clinicians will typically recommend staying with this dose. However, if you do not experience the desired effects with a 50 mg, many experts will recommend increasing the dose to 100 mg.
For most men with ED who take a sildenafil dosage of 100 mg, the effects usually last about four hours. This offers a comfortable time frame that is usually long enough for a user and his partner to get into the mood for sexual activity. A four-hour timespan allows enough time for spontaneity, without the need to hurry circumstances. Erectile dysfunction pills like these are easy to use as and most men experience positive erection results. Many men claim this medication has helped restore their sex lives.
Women tend to differ slightly from men when it comes to the pharmacokinetics of medications in general. The pharmacokinetics of a medicine refers to the metabolism, absorption, distribution and ultimately, the elimination of a substance. On average, women have lower body weights than men and this can affect how long a medication stays effective in the body. When it comes to sildenafil for women, however, the difference is negligible and women can also expect the effects to last about four to six hours. In medical research, women are usually treated with a 50 mg dosage. This dosage regimen has been shown to be well tolerated among women with little chance of sildenafil side effects.
Generic Viagra is available at leading online pharmacies. Since the patent for Viagra expired in 2013, an increasing number of men and women are using this treatment as the sildenafil price is now affordable. An online search for sildenafil reviews and ratings will reveal how most people benefit from excellent results.
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